Comparison Of Magnesium Sulfate Versus Nifedifine In Preterm Labour

Abstract

Objectives: To compare the efficacy of Magnesium sulfate versus nifedifine in pregnant women with preterm labour.                                                                                                                 

Materials and Methods:  Following Ethical Committee approval, 120 patients meeting inclusion criteria were enrolled with informed consent. Group A received oral nifedipine (30 mg loading dose, then 20–30 mg every 4–6 hours), and Group B received intravenous magnesium sulfate (4 g loading dose, then 1 g/hour). Monitoring was done every 4 hours, and efficacy was assessed at 48 hours. Data were collected using a predesigned questionnaire and analyzed with SPSS Version 25.

Results: A total of 120 patients with mean age of 31.68±6.74 years were enrolled, with 50% aged 18–30 years, 35% aged 31–40 years, and 15% over 40 years. Group A showed 46.7% efficacy, while Group B showed 71.7%. Gestational age averages were 31.93±2.98 weeks (Group A) and 31.76±2.75 weeks (Group B). Stratification by age, parity, gestational age, and gravida revealed no significant differences in efficacy across subgroups, though Group B consistently demonstrated slightly better outcomes.

Conclusion: Magnesium sulfate and nifedipine effectively manage preterm labor, with magnesium sulfate slightly better at delaying delivery, while nifedipine has fewer maternal side effects. Further studies are needed to refine their use and assess neonatal outcomes.